Figure 3: Polygonum multiflorum and Codonopsis pilosula Granule effectively reduces the percent of the aortic area containing lipid deposits and blood lipid levels in ApoE^−/− and p66shc^−/+ mice. (a) Gross staining with oil red O showed that the percent area of lipid deposition in the aorta was markedly reduced in the Polygonum multiflorum and Codonopsis pilosula Granule group. **P < 0.01 versus WT group, *P < 0.05 versus WT group,^##P < 0.01 versus Saline group,^#P < 0.05 versus WT group; t-test. (b) Polygonum multiflorum and Codonopsis pilosula Granule significantly improves blood lipid profile in ApoE^−/− and p66shc^−/+ mice. Serum TG, TC and LDL-C levels were markedly reduced while serum HDL-C level was significantly elevated in the Polygonum multiflorum and Codonopsis pilosula Granule group. **P < 0.01 versus the WT group, *P < 0.05 versus the WT group,^##P < 0.01 versus the Saline group,^#P < 0.05 versus the WT group; t-test