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   2020| January-March  | Volume 3 | Issue 1  
    Online since March 30, 2020

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Cell therapy of critical limb ischemia: A review of preclinical and clinical research in China
Lianming Liao
January-March 2020, 3(1):21-31
Critical limb ischemia (CLI) is the advanced stage of peripheral artery diseases and is characterized by limb pain. Current available treatments for CLI include pharmacological agents, bypass surgery, and endovascular therapy. When these conventional therapies fail, some patients may eventually suffer from amputation because of long-term blood flow insufficiency to the affected extremity. Novel therapeutic approaches are emergently needed. At present, proangiogenic gene/protein therapies and stem cell-based proangiogenic therapies have been proposed, and the promising results have been reported. Gene-modified stem cells and pretreated stem cells have been evaluated in the animal models. Proper bioscaffolds are also used to increase the survival and engraftment of delivered stem cells. Here, we address the current situation of stem cell research for CLI in China.
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Outcome of laparoscopic uterine artery occlusion for uterine fibroids on ovarian function and complications in patients with uterine fibroid
Guanlan Liu, Yuan Dong, Xiuying Zhang, Ying Liu
January-March 2020, 3(1):1-5
Objective: The aim of this study is to investigate the outcome of laparoscopic uterine artery occlusion (LUAO) on ovarian function in the treatment of uterine fibroid and its influence on complications. Materials and Methods: A total of 61 patients with uterine fibroid accept LUAO from January 2013 to December 2015 were selected as the research objects. The changes of ovarian hormone secretion volume, internal blood supply of uterine fibroid, uterine volume, fibroid volume, and the occurrence of complications were observed before and 3, 6, 12, and 24 months after surgery. These results were compared with the outcomes of 63 patients with uterine fibroid accept myomectomy. Results: Compared with myomectomy treatment, the length of intraoperative blood loss, operation time, and hospitalization time of patients in the LUAO group were shorter (P < 0.05). Menstruation characteristics, uterine volume, and uterine fibroid volume postoperation were better than the prior ones in the LUAO group (P < 0.05). The ovarian secretion of luteinizing hormone, estradiol, and follicle-stimulating hormone levels in patients in the following 24 months after surgery were not statistically different in two groups (P > 0.05), and the pelvic floor function had similar results. Conclusion: Uterine fibroid treated by LUAO is effective, it can decrease the internal blood supply of uterine fibroid, narrow the volume of uterine fibroid, and little impaction on ovarian function. Hence, this kind of treatment is worthy of promotion.
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Polygonum multiflorum and Codonopsis pilosula granule alleviates atherosclerosis by inhibiting the expression of DAB2IP-ASK1 pathway in vascular endothelial cells
Jiajia Zheng, Hu Zhang, Jianming Guo, Fangfang Dou, Jiulin Chen, Zhihua Yu, Chuan Chen, Te Liu
January-March 2020, 3(1):6-14
Background: Atherosclerosis is a chronic disease characterized by lipid accumulation, apoptosis and necrosis, smooth muscle cell proliferation and local inflammation. Polygonum multiflorum & Codonopsis pilosula Granule (PmCp Granule), akidney-tonifying compound used in Chinese medicine, has been used for the clinical treatment of atherosclerosis for the past 10 years and exhibits good therapeutic effects. Aims and Objectives: We want to prove that PmCp Granule inhibits the expression of the DAB2IP-ASK1 pathway in vascular endothelial cells, thereby alleviating the development of atherosclerosis. Materials and Methods: Blood lipid biochemical test and histopathology H&E staining were used to determine the efficacy of the PmCp Granule. qPCR and western blot were used to determine the expression of DAB2IP-ASK1 pathway. Results: The results of pathology assay showed that the plaque area, volume fraction of collagen fibers and lipid area in the aortic root was markedly reduced in the PmCp Granule group compared with the Saline group. Besides, the peripheral blood levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol were statistically significantly increased, whereas the high-density lipoprotein cholesterol was statistically significantly decreased in the PmCp Granule group in comparison to the control group. Finally, the results of western blot analysis showed that the expression levels of the proteins related to the DAB2IP-ASK1 pathway were significantly lower in the vascular endothelial cells of PmCp Granule group compared to control group. Conclusion: the present study demonstrated that PmCp Granule significantly alleviated the development of atherosclerosis in mice. The main mechanism of action of PmCp Granule involved the inhibition of the expression of the DAB2IP-ASK1 pathway in vascular endothelial cells.
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The beneficial enlightenment of thoracic endovascular aortic repair for traumatic Type B aortic dissection with long-term follow-up: A single-center experience sharing
Yongfu Xie, Shiying Wang, Qingsheng Lu
January-March 2020, 3(1):15-20
Abstract: Backgroud: Traumatic Aortic Dissection is a emergency that patients will face soon death, even there is no enough time to transport patient to the hospital. In this study we retrospectively analyze the long-term therapeutic effects of endovascular treatment of traumatic Type B aortic dissection to get some inspiration for the next step treatment and to provide a useful guidance. Method: 21 patients with Stanford type B aortic dissection caused by trauma endovascular treatment after strict condition assessment in our vascular center from December 1999 to May 2012 was recruited into this retrospective study. The overall diameter of the aorta, the number of tears and the extent of the dissection were observed based on three-dimensional reconstruction of the CTA during the follow-up. The recurrence of the operation and the 2-year and 5-year survival rates were recorded. Conclusion: Endovascular treatment of traumatic aortic dissection increases the survival rate of these patients who cannot tolerate traditional open surgery. This survival benefit sustained throughout the long-term follow-up.
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Toward physiological assessment of venous obstruction and reflux
Fedor Lurie
January-March 2020, 3(1):32-32
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