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ORIGINAL ARTICLE
Year : 2021  |  Volume : 4  |  Issue : 3  |  Page : 63-69

High sensitivity C reactive protein level is associated with prognosis in patients with severe coronavirus disease 19 pneumonia


1 Department of Vascular Surgery, Secondary Xiangya Hospital, Central South University; Vascular Diseases Institute, Changsha, Hunan, China
2 Department of cardiovascular medicine, Secondary Xiangya Hospital, Central South University, Changsha; Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China
3 Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei; Respiratory intensive care unit, Secondary Xiangya Hospital, Central South University, Changsha, China
4 Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei; Department of Cardiac surgery, Secondary Xiangya Hospital, Central South University, Changsha, China
5 Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei; Department of Geratology, Secondary Xiangya Hospital, Central South University, Changsha, China
6 Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei; Intensive care unit, Secondary Xiangya Hospital, Central South University, Changsha, China
7 Department of Vascular Surgery, Secondary Xiangya Hospital, Central South University; Vascular Diseases Institute, Changsha, Hunan; Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China
8 Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei; Department of Oncology, Secondary Xiangya Hospital, Central South University, Changsha, China
9 Department of Vascular Surgery, Secondary Xiangya Hospital, Central South University; Vascular Diseases Institute, Changsha, Hunan; State key laboratory of cardiovascular diseases, Central of vascular surgery, Fuwai Hospital, National Centre for Cardiovascular disease, Chinese academic of Medical Sciences and Peking Union Medical College, Beijing, China
10 Department of Vascular Surgery, Secondary Xiangya Hospital, Central South University; Vascular Diseases Institute, No.139 Renmin Road-Changsha -410011, Hunan; Anti-2019-nCov pneumonia medical support group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, China

Correspondence Address:
Dr. Xin Li
Department of Vascular Surgery, Secondary Xiangya Hospital, Central South University, No.139 Renmin Road-Changsha-410011, Hunan, China. Vascular Diseases Institute, Central South University, Changsha, Hunan, China. Anti-2019-nCov Pneumonia Medical Support Group to Wuhan from Secondary Xiangya Hospital, Central South University at Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2589-9686.32192

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OBJECTIVES: The objective of the study is to describe the association of high-sensitivity C-reactive protein (hsCRP) in patients with severe coronavirus disease-19 (COVID-19) pneumonia and determine the relationship between hsCRP, prognosis, and other factors. METHODS: The hsCRP level and other clinical data of patients with severe COVID-19 pneumonia in Tongji Hospital were retrospectively reviewed. Unpaired t-test and Mann–Whitney test were used to compare difference in data between groups. Spearman analysis was used to analyze the correlation. RESULTS: Fifty-seven patients (25 male [43.9%] and 32 female [56.1%]) were included, and their condition was monitored for 28 days. The baseline hsCRP level was 35.5 ± 81.9 mg/L, and the hsCRP level of 49 patients increased (86.0%). Moreover, 45 (78.9%) patients recovered to ordinary/mild COVID-19 pneumonia and 12 (21.1%) progressed to critical COVID-19 pneumonia or continued having severe pneumonia. In the recovered group, the hsCRP level decreased significantly (P = 0.0023). The hsCRP level in the deteriorated group was significantly higher than that of the recovered group (P = 0.0019 and P = 0.0004). ΔhsCRP was significantly correlated with time from onset (P = 0.0151), prognosis (P = 0.0151), ΔD-dimer level (P = 0.0320), Δwhite blood cell count (P = 0.0018), and Δneutrophil count (P = 0.0061). CONCLUSIONS: Severe COVID-19 pneumonia is crucial to patient prognosis and manifests high hsCRP levels; decreased hsCRP level is associated with improved patient prognosis, but hsCRP level may not increase in patients with deteriorating conditions. Simultaneous increase in hsCRP and D-dimer levels may indicate risk for venous thromboembolism in COVID-19 patients.


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