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  Indian J Med Microbiol
 

Figure 4: Polygonum multiflorum and Codonopsis pilosula Granule effectively inhibits the activation of the DAB2IP-ASK1 pathway in vascular endothelial cells of ApoE−/− and p66shc−/+ mice. (a) The qPCR results showed that there were no statistically significant differences in the expression of the key factors of the DAB2IP-ASK1 pathway at the mRNA level between the WT, saline and drug intervention groups. (b) Western blot results showed that the protein expression levels of the key factors of the DAB2IP-ASK1 pathway were significantly decreased in the vascular endothelial cells of the mice of the Polygonum multiflorum and Codonopsis pilosula Granule group. (c) Immunofluorescence staining showed that the expression of two proteins, ASK1 and p38MAPK, was markedly reduced in the Polygonum multiflorum and Codonopsis pilosula Granule group

Figure 4: <i>Polygonum multiflorum</i> and <i>Codonopsis pilosula</i> Granule effectively inhibits the activation of the DAB2IP-ASK1 pathway in vascular endothelial cells of ApoE<sup>−/−</sup> and p66shc<sup>−/+</sup> mice. (a) The qPCR results showed that there were no statistically significant differences in the expression of the key factors of the DAB2IP-ASK1 pathway at the mRNA level between the WT, saline and drug intervention groups. (b) Western blot results showed that the protein expression levels of the key factors of the DAB2IP-ASK1 pathway were significantly decreased in the vascular endothelial cells of the mice of the <i>Polygonum multiflorum</i> and <i>Codonopsis pilosula</i> Granule group. (c) Immunofluorescence staining showed that the expression of two proteins, ASK1 and p38MAPK, was markedly reduced in the <i>Polygonum multiflorum</i> and <i>Codonopsis pilosula</i> Granule group