• Users Online: 15
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 1  |  Issue : 1  |  Page : 14-23

Autologous tissue patches acquire vascular identity depending on the environment


1 Department of Vascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, China; Department of Vascular and Endovascular Surgery, Yale University School of Medicine, CT, USA; Department of Physiology, Basic Medical College of Zhengzhou University, Henan, China
2 Department of Vascular and Endovascular Surgery, Yale University School of Medicine, CT, USA
3 Department of Physiology, Basic Medical College of Zhengzhou University, Henan, China
4 Department of Vascular Surgery, First Affiliated Hospital of Zhengzhou University, Henan, China; 4Department of Surgery, VA Connecticut Healthcare System; Yale University School of Medicine, CT, USA

Correspondence Address:
Alan Dardik
Yale University School of Medicine, 10 Amistad Street, Room 437, PO Box 208089, New Haven, CT 06520-8089, USA

Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/VIT.VIT_9_18

Rights and Permissions

Background: Vascular identity is genetically determined but can be altered during surgical procedures. Methods: We hypothesized that the environment of the procedure critically alters the identity of autologous tissue patches implanted into the arterial or venous environment. Results: Autologous jugular vein or carotid artery was used as a patch to repair a rat aorta or inferior vena cava. In the aortic environment, patches contained neointimal cells that were CD34/ephrin-B2-dual positive but not CD34/Eph-B4-dual positive; patches expressed ephrin-B2, notch-4, and dll-4 but not Eph-B4 and COUP-TFII. In the venous environment, patches contained neointimal cells that were CD34/Eph-B4-dual positive but not CD34/ephrin-B2-dual positive; patches expressed Eph-B4 and COUP-TFIIbut not ephrin-B2, notch-4, and dll-4. Conclusion: These data show that autologous tissue patches heal by acquisition of the vascular identity determined by the environment into which they are implanted, suggesting some plasticity of adult vascular identity.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed39    
    Printed1    
    Emailed0    
    PDF Downloaded13    
    Comments [Add]    

Recommend this journal